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As seen on the cover of Cell (March 6th, 2009) Nevan Krogan, in collaboration with Kevan Shokat and colleagues, describes a comprehensive genetic analysis of the signaling machinery including all kinases and phosphatases using the E-Map approach. This work accurately recapitulated many well characterized signaling pathways and also identified unanticipated connections between different phosphorylation cascades. This approach lays the foundation for identifying combinations of genes, or genes operating at critical nodes at the intersection of signaling pathways, that can serve as appropriate therapeutic targets.
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QB3 Invitational SeminarQB3 and iPQB welcome Rachelle Gaudet from Harvard who will present on the topic of "Heat and Spice: Setting the Sensitivity of TRP Channels." Hosted by the L. Jan lab.
QB3 Invitational SeminarQB3 and iPQB welcome James Berger from UC Berkeley who will present his research in "Catching a motor in the act: the molecular basis for translocation and biased movement in hexameric helicases." Hosted by the D. Minor lab.
Nevan Krogan is an Assistant Professor in the Department of Cellular & Molecular Pharmacology with his lab in the 3rd floor-North neighborhood of Byers Hall. He originally came to qb3 in 2006 as a UCSF Fellow in the Systems Biology program after receiving his PhD at the University of Toronto. read more