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As seen on the cover of Cell (March 6th, 2009) Nevan Krogan, in collaboration with Kevan Shokat and colleagues, describes a comprehensive genetic analysis of the signaling machinery including all kinases and phosphatases using the E-Map approach. This work accurately recapitulated many well characterized signaling pathways and also identified unanticipated connections between different phosphorylation cascades. This approach lays the foundation for identifying combinations of genes, or genes operating at critical nodes at the intersection of signaling pathways, that can serve as appropriate therapeutic targets.
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Nevan Krogan is an Assistant Professor in the Department of Cellular & Molecular Pharmacology with his lab in the 3rd floor-North neighborhood of Byers Hall. He originally came to qb3 in 2006 as a UCSF Fellow in the Systems Biology program after receiving his PhD at the University of Toronto. read more